Triptans

Key points

• Triptans are specific 5-HT1B and 5-HT1D agonists used in the acute treatment of migraine. They are generally used first-line in combination therapy with an NSAID or paracetamol. Prescribing points
• should be taken as soon as possible after the onset of headache, rather than at onset of aura
• oral, orodispersible, nasal spray and subcutaneous injections are available Adverse effects
• 'triptan sensations' - tingling, heat, tightness (e.g. throat and chest), heaviness, pressure Contraindications
• patients with a history of, or significant risk factors for, ischaemic heart disease or cerebrovascular disease