Membranoproliferative Glomerulonephritis

Key points

• Membranoproliferative glomerulonephritis
• also known as mesangiocapillary glomerulonephritis
• may present as nephrotic syndrome, haematuria or proteinuria
• renal biopsy o electron microscopy: subendothelial and mesangium immune deposits of electron-dense material resulting in a 'tram-track' appearance Type 2 - 'dense deposit disease'
• causes: partial lipodystrophy (patients classically have a loss of subcutaneous tissue from their face), factor H deficiency