Paraneoplastic Syndromes Affecting the Nervous System

Key points

• Paraneoplastic syndromes affecting nervous system Lambert-Eaton myasthenic syndrome
• associated with small cell lung cancer (also breast and ovarian)
• antibody directed against pre-synaptic voltage gated calcium channel in the peripheral nervous system
• can also occur independently as autoimmune disorder Anti-Hu
• associated with small cell lung carcinoma and neuroblastomas