Haematology-Oncology · Pathway 32

Hairy Cell Leukaemia

Reference Linear

Key points

Hairy cell leukaemia is a rare malignant proliferation disorder of B cells. It is more common in males (4:1) Features
skin vasculitis in 1/3 patients
'dry tap' despite bone marrow hypercellularity
tartrate resistant acid phosphotase (TRAP) stain positive Management
chemotherapy is first-line: cladribine, pentostatin