Haematology-Oncology · Pathway 33

Chronic Lymphocytic Leukaemia

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Key points

Chronic lymphocytic leukaemia (CLL) is caused by a monoclonal proliferation of well-differentiated lymphocytes which are almost always B-cells (99%). It is the most common form of leukaemia seen in adults. Features
constitutional: anorexia, weight loss
bleeding, infections
lymphadenopathy more marked than CML Complications
hypogammaglobulinaemia leading to recurrent infections