Coeliac Disease: Investigation

Key points

• Coeliac disease is caused by sensitivity to the protein gluten. Repeated exposure leads to villous atrophy which in turn causes malabsorption.
• tissue transglutaminase (TTG) antibodies (IgA) are first- choice according to NICE
• endomyseal antibody (IgA)
• anti-gliadin antibody (IgA or IgG) tests are not recommended by NICE
• anti-casein antibodies are also found in some patients Jejunal biopsy