Whipple's Disease

Key points

• Whipple's disease is a rare multi-system disorder caused by Tropheryma whippelii infection. It is more common in those who are HLA-B27 positive and in middle-aged men Features
• malabsorption: diarrhoea, weight loss
• large-joint arthralgia
• lymphadenopathy
• skin: hyperpigmentation and photosensitivity