Gout: Predisposing Factors

Key points

• Gout is a form of microcrystal synovitis caused by the deposition of monosodium urate monohydrate in the synovium. It is caused by chronic hyperuricaemia (uric acid > 0.45 mmol/l) · NICE NG219 confirms the clinical diagnosis at a serum urate of 360 micromol/L or more. DECREASED EXCRETION of uric acid:
• drugs*: diuretics
• chronic kidney disease
• lead toxicity Increased production of uric acid
• myeloproliferative/lymphoproliferative disorder