Familial Mediterranean Fever

Key points

• Familial Mediterranean Fever (FMF, also known as recurrent polyserositis) is an autosomal recessive disorder typically presenting by the second decade
• More common in people of Turkish, Armenian, and Arabic descent
• Features: attacks typically last 1–3 days and include pyrexia, abdominal pain (due to peritonitis), pleuritic chest pain, and an erysipeloid rash on the lower limbs
• Management: colchicine may help reduce the frequency of attacks