Mixed Connective Tissue Disease

Key points

• Mixed connective tissue disease (MCTD, Sharp's syndrome) is a rare, heterogeneous, multi-system autoimmune disorder. It is a distinct clinical entity, but features of systemic lupus erythematosus (SLE),
• Male:female ratio 1:3
• Average age of presentation 30-40, may present in children
• Rare - incidence in adult population is estimated to be 2.1/million/year in one Norwegian study Presentation:
• Raynaud's phenomenon often precedes other symptoms and occurs in 90% of cases