Systemic Sclerosis

Key points

• Systemic sclerosis is a condition of unknown aetiology characterised by hardened, sclerotic skin and other connective tissues.
• Raynaud's may be first sign
• scleroderma affects face and distal limbs predominately
• associated with anti-centromere antibodies
• a subtype of limited systemic sclerosis is CREST syndrome: Calcinosis, Raynaud's phenomenon, oEsophageal dysmotility, Sclerodactyly, Telangiectasia Diffuse cutaneous systemic sclerosis