Sarcoidosis

Key points

• Sarcoidosis Sarcoidosis is a multisystem disorder of unknown aetiology characterised by non-caseating granulomas. It is more common in young adults and in people of African descent Features
• acute: erythema nodosum, bilateral hilar lymphadenopathy, swinging fever, polyarthralgia
• insidious: dyspnoea, non-productive cough, malaise, weight loss
• skin: lupus pernio
• hypercalcaemia: macrophages inside the granulomas cause an increased conversion of vitamin D to its active form (1,25- dihydroxycholecalciferol) Syndromes associated with sarcoidosis Lofgren's syndrome is an acute form of the…