Pharmacology · Pathway 55
HRT
Key points
- HRT: oestrogen alone (hysterectomised) or combined oestrogen + progestogen (intact uterus — unopposed oestrogen risks endometrial cancer).
- Risks: VTE, breast cancer (combined > oestrogen-only), stroke.
- Benefits: symptom relief, osteoporosis protection.
- Tibolone: steroid with oestrogenic/progestogenic/androgenic activity.
Decision points in this pathway
- Uterus intact?
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