Pharmacology · Pathway 51
Combined Oral Contraceptive Pill
Key points
- COCP: oestrogen + progestogen — inhibits ovulation (mainly progestogen effect on LH/FSH).
- Contraindications include: VTE history, migraine with aura, smokers ≥ 35 years (> 15/day), breast cancer, uncontrolled hypertension.
- Risks: VTE (small absolute risk), hypertension, stroke/MI (in smokers > 35).
- Missed pill rules depend on preparation; enzyme-inducing drugs reduce efficacy.
- Benefits: reduced ovarian/endometrial cancer risk, cycle control.
Decision points in this pathway
- Contraindication? (VTE history · migraine with aura · smoker ≥ 35 y · breast cancer · uncontrolled HTN)
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