Fetal Alcohol Syndrome & Zieve's Syndrome

Key points

• Fetal alcohol syndrome: growth retardation, characteristic facies (short palpebral fissures, smooth philtrum, thin upper lip), CNS abnormalities, cardiac defects.
• No safe level of alcohol in pregnancy is established.
• Zieve's syndrome: triad of haemolytic anaemia + jaundice + hyperlipidaemia in alcoholic liver disease.
• Zieve's typically resolves with alcohol abstinence.