Cephalosporins

Key points

• Cephalosporins are a type of β-lactam antibiotic which are bactericidal. They are less susceptible to penicillinases than penicillins. β-lactam antibiotics work by disrupting the synthesis of bacterial cell walls,
• Changes to penicillin-binding-proteins (PBPs), which are types of transpeptidases (enzymes produced by bacteria that cross-links peptidoglycan chains to form rigid cell walls)
• bactericidal. They are less susceptible to penicillinases than
• β-lactam antibiotics work by disrupting the synthesis of