Haematology-Oncology · Pathway 81

Wiskott-Aldrich Syndrome

Reference Linear

Key points

Wiskott-Aldrich syndrome causes primary immunodeficiency due to combined B- and T-cell dysfunction
Inherited in an X-linked recessive fashion; thought to be caused by mutation in the WASP gene
Features: recurrent bacterial infections (e.g. chest), thrombocytopaenia, low IgM levels, eczema