Cyclophosphamide

Key points

• Cyclophosphamide is an alkylating agent used in the management of cancer and autoimmune conditions. It works by causing cross-linking of DNA Adverse effects
• haemorrhagic cystitis: incidence reduced by the use of hydration and mesna
• myelosuppression
• transitional cell carcinoma Mesna
• 2-mercaptoethane sulfonate Na