Prothrombin Complex

Key points

• NICE published guidelines on the use of blood products in 2015. Fresh frozen plasma (FFP)
• most suited for 'clinically significant' but without 'major haemorrhage' in patients with a prothrombin time (PT) ratio or activated partial thromboplastin time (APTT) ratio > 1.5
• typically 150-220 mL
• can be used prophylactically in patients undergoing invasive surgery where there is a risk of significant bleeding
• In contrast to red cells, the universal donor of FFP is AB blood because it lacks any anti-A or anti-B antibodies Cryoprecipitate