Antithrombin Iii Deficiency

Key points

• Antithrombin III deficiency is an inherited cause of thrombophilia occurring in approximately 1:3,000 of the population. Inheritance is autosomal dominant. Antithrombin III inhibits several clotting factors, primarily thrombin,
• recurrent venous thromboses
• arterial thromboses do occur but are uncommon Management
• thromboembolic events are treated with lifelong warfarinisation
• heparinisation during pregnancy*