Haematology-Oncology · Pathway 5

Haemolytic Anaemias: by Site

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Key points

In intravascular haemolysis free haemoglobin is released which binds to haptoglobin. As haptoglobin becomes saturated haemoglobin binds to albumin forming methaemalbumin (detected by Schumm's test).
mismatched blood transfusion
G6PD deficiency*
red cell fragmentation: heart valves, TTP, DIC, HUS
paroxysmal nocturnal haemoglobinuria