Myelofibrosis

Key points

• a myeloproliferative disorder
• thought to be caused by hyperplasia of abnormal megakaryocytes
• the resultant release of platelet derived growth factor is thought to stimulate fibroblasts
• haematopoiesis develops in the liver and spleen Features
• e.g. elderly person with symptoms of anaemia e.g. fatigue (the most common presenting symptom)