Haematology-Oncology · Pathway 36
Chronic Myeloid Leukaemia
Key points
- The Philadelphia chromosome is present in more than 95% of patients with chronic myeloid leukaemia (CML). It is due to a translocation between the long arm of chromosome 9 and 22 - t(9:22)(q34; q11).
- anaemia: lethargy
- weight loss and sweating are common
- splenomegaly may be marked → abdo discomfort
- spectrum of myeloid cells seen in peripheral blood