Waldenstrom's Macroglobulinaemia

Key points

• Waldenstrom's macroglobulinaemia is an uncommon condition seen in older men. It is a lymphoplasmacytoid malignancy characterised by the secretion of a monoclonal IgM paraprotein Features
• monoclonal IgM paraproteinaemia
• systemic upset: weight loss, lethargy
• hyperviscosity syndrome e.g. visual disturbance
• hepatosplenomegaly