Myeloma: Features

Key points

• Multiple myeloma is a neoplasm of the bone marrow plasma cells. The peak incidence is patients aged 60-70 years. Clinical features
• bone disease: bone pain, osteoporosis + pathological fractures (typically vertebral), osteolytic lesions
• hypercalcaemia (see below)
• renal failure
• other features: amyloidosis e.g. Macroglossia, carpal tunnel syndrome; neuropathy; hyperviscosity Investigations