Drug-Induced Pancytopaenia

Key points

• Drug causes of pancytopaenia
• Antibiotics: trimethoprim, chloramphenicol
• Anti-rheumatoid drugs: gold, penicillamine
• Anti-epileptics: carbamazepine
• Sulphonylureas: e.g. tolbutamide (may cause both agranulocytosis and pancytopaenia)