Gastroenterology · Pathway 89

Primary Sclerosing Cholangitis

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Key points

Primary sclerosing cholangitis is a biliary disease of unknown aetiology characterised by inflammation and fibrosis of intra and extra-hepatic bile ducts Associations
ulcerative colitis: 4% of patients with UC have PSC, 80% of patients with PSC have UC
Crohn's (much less common association than UC)
cholestasis: jaundice and pruritus
right upper quadrant pain