Coagulopathy of Liver Disease

Key points

• In liver failure all clotting factors are low, except for factor VIII which is paradoxically supra-normal. This is because factor VIII is synthesised in endothelial cells throughout the body,
• In liver failure all clotting factors are low, except for factor VIII
• which is paradoxically supra-normal. This is because factor VIII
• is synthesised in endothelial cells throughout the body, unlike
• the other clotting factors which are synthesised purely in