Drug-Induced Liver Disease

Key points

• Drug-induced liver disease is generally divided into hepatocellular, cholestatic or mixed. There is however considerable overlap,
• sodium valproate, phenytoin
• anti-tuberculosis: isoniazid, rifampicin, pyrazinamide
• nitrofurantoin The following drugs tend to cause cholestasis (+/- hepatitis): oral contraceptive pill
• antibiotics: flucloxacillin, co-amoxiclav, erythromycin*