Meglitinides

Key points

• Meglitinides Meglitinides (e.g. repaglinide, nateglinide)
• increase pancreatic insulin secretion
• like sulfonylureas they bind to an ATP-sensitive potassium (K-ATP) channel on the cell membrane of pancreatic beta cells
• often used for patients with an erratic lifestyle
• adverse effects include weight gain and hypoglycaemia (less so than sulfonylureas)